Mick McCarthy will use all his insider knowledge to defeat a side that have won once in six at home.
Ipswich are searching for a first goal in four Championship matches against the black-country club.
Wanderers have ended the calendar year on a winning note once in eight seasons, when defeating Liverpool 1-0 at Anfield in 2010.
If Ipswich are to progress up the table then taking points for their nearest rivals will be key.
So they will be looking for a fourth away victory against a bottom-half club, having already taken maximum points from Bolton, Birmingham and Charlton and gained a point at Barnsley.
Winger Bjorn Sigurdarson may be given a starting place after impressing in the win as might defender Richard Stearman who is a transfer target for Town.
Wolves manager Stale Solbakken is expected to make changes to his side after their 3-0 home defeat against Peterborough on Boxing Day.
The striker will want to impress prospective new employers
Despite the risk of fatigue for some, Ipswich manager Mick McCarthy may keep faith with an unchanged side for a fifth successive match.
He scores at will
Ipswich to win 1-0
Home to Brighton on January 1